Do You Know The Role Of Mangiferin Powder?

What Is Mangiferin Powder?

Mangiferin, also known as Guanzhimuning or mangiferin, is a carbon ketone glycoside of tetrahydroxypyridone, which belongs to the flavonoids of bisphenone, mainly derived from the dried rhizomes of the perennial herb Anemarrhena of Liliaceae. , the leaves, fruits, and bark of plants almonds and mangoes, and the roots of the five-story Chemicalbook floor of the genus Pentaphyllum, etc.; it has the functions of relieving cough, relieving asthma and expectorating phlegm, immune, anti-inflammatory and analgesic, protecting liver and gallbladder, It has various pharmacological activities such as anti-lipid peroxidation, anti-cancer, anti-diabetic, antibacterial, anti-viral, etc. At present, the main clinical applications are mango cough tablets, mango cough capsules, mangiferin tablets, mangiferin dripping pills, and these drugs are only limited to For respiratory diseases.Suppliers of our Food Raw Materials.

Pharmacological Action:

1. Antioxidant Effect

Due to the special structure of mangiferin, there are multiple phenolic hydroxyl groups in the molecule, and the phenolic hydroxyl groups are just important groups for scavenging free radicals and reactive oxygen species. The mechanism of its action on free radicals can be attributed to two aspects: on the one hand, it acts directly on scavenging free radicals, on the other hand, it acts on iron and copper ions to reduce their further reaction with free radicals.

2. Anti-Tumor Effect

The occurrence of leukemia is related to the disorder of cell cycle regulation, and there is a close relationship between cell cycle regulation and the expression of telomerase activity. Therefore, the study of abnormal regulation of telomerase and cell cycle has become a new direction to explore the occurrence and treatment of leukemia. The occurrence of leukemia is related to the disorder of cell cycle regulation, and there is a close relationship between cell cycle regulation and the expression of telomerase activity. Therefore, the study of abnormal regulation of telomerase and cell cycle has become a new direction to explore the occurrence and treatment of leukemia.It are also Health Product Raw Materials.

3. Neuroprotective Effect

Mangiferin with polyphenolic structure can protect neurons by reducing the influx of Ca2+ and the degree of oxidative stress, thereby reducing cell death caused by glutamate in neurons.

4. Antiviral Effect

It has in vitro anti-herpes simplex virus type I (HSV-I) effect with a plaque reduction rate of 56.8%, and its antiviral effect is attributed to its ability to inhibit intracellular viral replication.

5. Antipyretic Effect

It has a good antipyretic effect on the experimental animal model of fever caused by endotoxin, which is positively correlated with the dose, and has a good protective effect on thermal injury.

6. Analgesic Effect

It has a significant analgesic effect on pain induced by acetic acid and hot plate test. Compared with naloxone hydrochloride, it is found that mangiferin-induced analgesia is not dependent on opioid receptors. .

7. Anti-Parasitic Effect

Mangiferin has obvious inhibitory effect on Cryptosporidium parvum in young mice. Effects of mangiferin on mice infected with the nematode, Trichinella spiralis.

8. Anti-Diabetic Effect

After oral administration of mangiferin and its glucoside, the blood sugar level of normal mice did not change, but it could reduce the blood sugar concentration of KK-Ay mice, an animal model of spontaneous diabetes, and the serum insulin level also decreased. Fructin and its glucosides may exhibit antidiabetic activity through insulin sensitization.

9. Hepatoprotective And Choleretic Effects

For the protection of the liver, mangiferin can stabilize the lysosomal membrane and directly inhibit the activity of lysosomal acid phosphatase. Mangiferin also has obvious choleretic effect.

10. Effects On The Central Nervous System

Mangiferin has obvious central nervous system excitatory effect. Mangiferin has the effect of removing lipid peroxides in brain tissue, reducing the damage of lipid peroxides to neurons, thereby protecting the normal function of neurons.

11. Effects On The Respiratory System

It has adrenal glucocorticoid-like anti-inflammatory effect, can reduce capillary permeability, and its anti-inflammatory response rate reaches 38%. Due to the anti-inflammatory effect of mangiferin, it has a certain effect on bronchial asthma, which is manifested as (1) the induction time of asthma is significantly longer than that in the asthma group; (2) the degree of asthma is relieved, and the incidence of convulsions is significantly lower than that in the asthma group; (3) the emphysema is caused Significantly reduced, the infiltration of inflammatory cells in the lung was significantly less than that in the asthma group, and the lung/body weight ratio was significantly lower than that in the asthma group, and was close to the dexamethasone group. At the same time, mangiferin can reduce serum NO and endothelin-1 (ET-1) levels in bronchoalveolar lavage fluid, and play a certain preventive effect on asthma attacks. The combined use of mangiferin and dexamethasone can improve the efficacy.

Extraction method of mangiferin powder:

4. Ultrasonic-assisted extraction process The ultrasonic-assisted extraction process has the advantages of simplicity, short time consumption, energy saving, etc., and has good development and application prospects.